Streptokinase Injection: Uses, Dose, Antidote, Side Effects, and Price
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Streptokinase injection is a life-saving medication used to dissolve blood clots that can block vital blood vessels, leading to serious health emergencies. Derived from certain strains of Streptococcus bacteria, streptokinase works by activating the body’s natural clot-dissolving system, breaking down fibrin—the key component of blood clots.
It is classified as a thrombolytic (clot-busting) agent and is widely used in the management of conditions like heart attacks, pulmonary embolism, and deep vein thrombosis. Early and appropriate use of streptokinase can significantly improve outcomes by restoring blood flow to affected tissues and preventing permanent damage.
Due to its powerful effects, it is administered in controlled medical settings such as hospitals, and usage is guided carefully by trained healthcare professionals.
How Streptokinase Works?
Streptokinase is a clot-dissolving (thrombolytic) enzyme derived from certain strains of Streptococcus bacteria. It works by turning on the body’s natural system to break down clots.
Normally, the blood contains an inactive protein called plasminogen. Streptokinase binds to plasminogen and converts it into an active enzyme called plasmin. Plasmin’s role is to break down fibrin — the structural framework of blood clots.
By breaking down fibrin, streptokinase effectively dissolves the clot, restores normal blood flow, and helps prevent tissue damage caused by blocked blood vessels.
In simple terms, streptokinase “kickstarts” the body’s internal mechanism to destroy harmful clots that could otherwise cause a heart attack, stroke, or lung blockage (pulmonary embolism).
How Streptokinase Injection Works
Streptokinase injection is administered directly into a vein (intravenous infusion) in a hospital setting, usually in emergencies like heart attacks or pulmonary embolisms.
Once inside the bloodstream, the streptokinase in the injection immediately binds to plasminogen, starting the clot-dissolving process quickly.
Doctors monitor patients closely during and after the injection, as clot breakdown can sometimes cause bleeding or sudden changes in blood pressure.
The timing, dosage, and careful supervision of the streptokinase injection are critical to maximize its benefits and minimize risks.
Streptokinase Injection Uses
Streptokinase injection is a powerful medication primarily used to dissolve dangerous blood clots that can block blood vessels and cause serious health issues. It belongs to a class of drugs known as thrombolytics or clot-busters.
Here are the main medical uses of streptokinase injection:
1. Acute Myocardial Infarction (Heart Attack)
- Streptokinase is widely used during heart attacks caused by blocked coronary arteries.
- It helps restore blood flow to the heart muscle, minimizing damage and improving survival rates.
- It is most effective when given within a few hours of symptom onset.
2. Pulmonary Embolism
- In cases where a blood clot blocks an artery in the lungs (pulmonary embolism), streptokinase is used to dissolve the clot.
- This improves oxygen exchange and reduces the risk of life-threatening complications.
3. Deep Vein Thrombosis (DVT)
- Streptokinase helps break down clots formed in deep veins, usually in the legs.
- Treating DVT promptly can prevent serious conditions like pulmonary embolism.
4. Arterial Thrombosis and Embolism
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Used to treat blood clots in arteries that can lead to strokes or limb ischemia (loss of blood supply to limbs).
5. Occluded Arteriovenous Cannulas
- Sometimes, catheters used in dialysis or intravenous therapy get blocked by clots.
- Streptokinase can be used to clear these obstructions without needing to replace the catheter.
How Streptokinase Injection is Supplied
Streptokinase injection usually comes as a powder that needs to be mixed with a sterile liquid before it can be given.
It is available in the following standard packaging:
| Category | Details |
|---|---|
|
Form |
Lyophilized powder for injection
|
|
Strengths Available
|
250,000 IU per vial 750,000 IU per vial 1,500,000 IU per vial |
|
Packaging
|
Sterile vial containing streptokinase powder Usually accompanied by sterile water for reconstitution |
|
Storage Conditions |
Store between 2°C to 8°C (Refrigerated) Protect from light Do not freeze |
Streptokinase Injection Dose
The dosage of Streptokinase Injection depends on the condition being treated, the patient’s weight, and clinical urgency. It must always be administered under strict medical supervision, usually in a hospital setting.
➔ Standard Dosage for Acute Myocardial Infarction (Heart Attack):
- Loading dose: 250,000 IU (International Units) administered intravenously over 30 minutes.
- Maintenance dose: Followed by 1,500,000 IU infused over 60 minutes.
➔ Dosage for Pulmonary Embolism and Deep Vein Thrombosis (DVT):
- Initial dose: 250,000 IU over 30 minutes (as an infusion).
- Follow-up dose: 100,000 IU per hour for 24 to 72 hours, depending on the patient’s response and physician’s decision.
➔ Dosage for Arterial Thrombosis or Occluded Catheters:
- It depends on how big the clot is and the patient’s condition.
- A typical catheter clearance dose ranges from 250,000 IU diluted and instilled directly into the catheter.
Where to Buy Streptokinase Injection?
Livealth Biopharma is a trusted global supplier of Streptokinase Injection, offering reliable pharmaceutical solutions with international shipping. Partner with Livealth Biopharma to source high-quality Streptokinase Injection for your healthcare needs.
Common Side Effects of Streptokinase Injection
While Streptokinase is highly effective in dissolving dangerous blood clots, it can cause certain side effects. Most of these are manageable with medical supervision, but some may need immediate attention. Common Side Effects:
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Bleeding:
This is the most common side effect. It can include bleeding from the gums, nosebleeds, or bleeding at the injection site. -
Low Blood Pressure (Hypotension):
May lead to symptoms like dizziness, weakness, or fainting. -
Allergic Reactions:
Mild reactions such as skin rashes, itching, flushing, or fever may occur. In rare cases, severe allergic responses like anaphylaxis can happen. -
Fever and Chills:
Some patients report temporary fever, chills, or shaking after receiving the medication. -
Nausea and Vomiting:
These are relatively common but usually mild gastrointestinal symptoms. -
Shortness of Breath:
Rarely, this can occur due to allergic or systemic reactions. -
Chest Pain:
Any chest pain during treatment should be taken seriously and evaluated immediately to rule out complications.
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